The report from the Centers for Medicaid & Medicare Services (CMS) analyzes the performance of nearly 500 quality measures used in CMS’s quality and value-based incentive payment programs. It provides patients and families, clinicians, measure developers, federal partners, and researchers with updates on progress toward reducing disparities across the measure portfolios. For example, rural/urban disparities were most often detected in quality measures addressing Wellness and Prevention and Chronic Conditions; however, several measures of Person-Centered Care no longer show rural/urban disparities. Findings from focus groups underscore the need to develop measures that address bias in care delivery, deficits in cultural competence, and social drivers of health relative to unmet health needs, poor access, and low health literacy.