The Centers for Disease Control and Prevention (CDC) recently issued a new Clinical Practice Guideline for Prescribing Opioids for Pain. This guideline provides recommendations for clinicians providing pain care, including those prescribing opioids, for outpatients over 18 years of age. It updates the previous CDC guideline and includes recommendations for managing acute (duration of less than one month), subacute (duration of 1–3 months) and chronic (duration of more than three months) pain.