The U.S. Health and Human Services (HHS) has released a Viral Hepatitis National Strategic Plan for the United States: A Roadmap to Elimination (2021-2025). The plan is a crucial element to advancing elimination efforts and will serve as a framework to implement strategies and address the rising number of hepatitis cases. The plan also recognizes the syndemic of viral hepatitis, HIV, STIs and substance use disorders, the mitigation of which will require integrated, interventional strategies that address whole-person health. The integrated approach is critical for the success of prevention and treatment strategies as the opioid use crisis continues to drive increases in hepatitis cases.