During Calendar Year (CY) 2021, Pennsylvania (exclusive of Philadelphia) reported a 28% increase in Early Syphilis from CY 2020. The reported 1,418 cases in CY 2021 represents the highest number of Early Syphilis cases in more than 30 years. Additionally, during CY 2021, there was also a reported 36% increase in Early Syphilis cases in females of whom 90% were child-bearing age. Read more.