HIV Prevention Among Persons Who Inject Drugs: Rural and Urban Differences. In an open access article, researchers examined how stigma operates in rural and urban settings in relation to PrEP, a medicine for people who are at high risk for HIV from sex or injection drug use. The investigation showed willingness to use PrEP in both urban and rural settings. However, stigma against drug use, HIV, and sexualities were identified as barriers to PrEP uptake, particularly in the rural setting.