The U.S. Preventive Services Task Force released a final recommendation statement on pre-exposure prophylaxis (PrEP) to prevent the acquisition of HIV. Healthcare professionals should prescribe PrEP to people at increased risk for HIV. The Task Force has also developed a clinical discussion guide as part of its Let’s Talk About It series to support conversations between clinicians and their patients about whether PrEP may be right for them. To view the recommendation, the evidence on which it is based, a summary for clinicians, and the clinical discussion guide, please go here.