The Centers for Medicare & Medicaid Services (CMS) updated Chapter 10 of the Medicare Program Integrity Manual to instruct Medicare Administrative Contractors (MACs) on how to process enrollment applications for rural hospitals and Critical Access Hospitals converting to the Rural Emergency Hospital (REH) designation beginning January 1, 2023. Included are instructions on how the change of enrollment form CMS-855A should be completed and the steps the MACs should take to review, approve, or deny the applications. This guidance reflects the enrollment requirements for REHs published in the final 2023 Medicare Hospital Outpatient Prospective Payment Rule.