The Centers for Disease Control and Prevention (CDC) has issued a Health Alert Advisory (HAN) for recent HIV clusters and outbreaks occurring across the U.S. in people who inject drugs and considerations during the COVID-19 pandemic. The purpose of the HAN is to alert public health departments and healthcare providers to the possibility of new injection-related HIV infections and outbreaks. It provides guidance for preventing, identifying, and responding to HIV among people who inject drugs. It also provides considerations for delivering services in the context of the COVID-19 pandemic.